SEE WHAT YOU CAN ACHIEVE WITH PYZCHIVA® (ustekinumab-ttwe)

Learn more about PYZCHIVA, an FDA-approved alternative to Stelara® (ustekinumab)

Why choose PYZCHIVA?

PYZCHIVA is:

A biosimilar to Stelara®, and can be used in its place

FDA approved to treat all of the same conditions as Stelara®

Brought to you by Sandoz, a company with 25+ years of experience in biosimilars

WHAT IS A BIOSIMILAR?

Although they are not exactly the same, you can think of a biosimilar as being like a generic medicine. Like generics, biosimilars can be used in place of a name-brand medicine because they deliver results that are just as safe and effective. As a biosimilar to Stelara®, PYZCHIVA can be used in place of Stelara®.

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What can you expect with PYZCHIVA® (ustekinumab-ttwe)?

An FDA-approved treatment

PYZCHIVA is an FDA-approved biosimilar to Stelara® (ustekinumab). This means PYZCHIVA has been thoroughly studied and proven to be as safe and effective as Stelara®. It also means PYZCHIVA can be used in place of Stelara®. PYZCHIVA is FDA approved to treat Crohn's disease, ulcerative colitis, plaque psoriasis, and psoriatic arthritis. Please see full uses for PYZCHIVA below.

The same symptom relief as Stelara®

The FDA approved PYZCHIVA because it is proven to have the same effectiveness, safety, and quality as Stelara®. This means you can expect the same results with PYZCHIVA as Stelara®. 

The same dosing schedule

PYZCHIVA has the same dosing schedule as Stelara®, so switching is straightforward.

  • PYZCHIVA is available in a prefilled syringe
  • If you have Crohn’s disease or ulcerative colitis and have never taken this kind of medicine before, your first dose of PYZCHIVA will be given through an intravenous (IV) infusion

Support from day one

Sandoz One Source offers a number of support services to people taking PYZCHIVA, including a Co-Pay Program, access to Case Managers, 1:1 injection support, and more.

Real, achievable results

PYZCHIVA delivers results for people with different autoimmune conditions. Individual results may vary. Please see full uses for PYZCHIVA below.

See the results of medical studiesa in adults with:

  • The majority of people, mostly new to biologic treatment (56%), experienced relief from their symptoms within 6 weeksb
  • More than half (53%) were in remission after one year of treatmentb,c

bIn people who were new to or had not failed on biologic therapy.

cThese results came from studies that included people who failed on other medicines or did not tolerate those medicines well. This included biologic medicines.

  • Within 8 weeksb,c:
    • The majority of people (58%) experienced relief from their symptoms
    • Approximately 1 in 5 people were in remission
  • Within 1 yearb,c:
    • Almost half (45%) were in remission

bIn people who were new to or had not failed on biologic therapy.

cThese results came from studies that included people who failed on other medicines or did not tolerate those medicines well. This included biologic medicines.

  • The majority of people (approximately 75%) saw clearer skin in 12 weeks

PYZCHIVA is also FDA approved for children with plaque psoriasis who are aged 6-17. This means it has been proven to be safe and effective in children of these ages. Your child’s doctor can help you decide if PYZCHIVA is the right treatment for them.

  • In 24 weeks, nearly half of people in the study (46%) experienced a 20% improvement in their joint symptoms

PYZCHIVA is also FDA approved for children with plaque psoriasis who are aged 6-17. This means it has been proven to be safe and effective in children of these ages. Your child’s doctor can help you decide if PYZCHIVA is the right treatment for them.

aBased on clinical studies with Stelara®. Only you and your doctor can decide if PYZCHIVA is right for you. Individual results may vary.

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Taking PYZCHIVA® (ustekinumab-ttwe)

PYZCHIVA is given as a shot under the skin.

A prefilled syringe injects the medicine as you manually push the plunger

Before your first injection, you should talk with your doctor about how to administer PYZCHIVA. Additional injection training and support is available through Sandoz One Source. For complete information on how to inject PYZCHIVA, please see the Instructions for Use in the full Prescribing Information.

PYZCHIVA is also available in a 45 mg vial for in-office or at-home administration by a healthcare provider.

Starting or switching to PYZCHIVA

  • If you are starting treatment with PYZCHIVA:

    • Your healthcare provider will talk to you about how often you'll get your PYZCHIVA shots
      • If you have Crohn's disease or ulcerative colitis, you will have a starter dose that is given through an IV infusion before you begin your shots
    • Your healthcare provider can give you your shots in their office, or you or a caregiver can be trained to inject your PYZCHIVA shots at home

  • If you are switching to PYZCHIVA:

    • PYZCHIVA has the same dosing schedule as Stelara® (ustekinumab), so switching is straightforward
      • There should be no changes in when you take your medicine
    • Your healthcare provider can give you your shots in their office, or you or a caregiver can be trained to inject your PYZCHIVA shots at home

Get support from

Sandoz One Source

Whether you’re starting or switching to PYZCHIVA®, our team is here to help at every step

PYZCHIVA Co-Pay Program

If you’re eligible, you could pay as little as $0 for PYZCHIVAd

  • If you qualify, you can start using your co-pay card right away
  • Your card doesn’t expire—you’ll be automatically re-enrolled every year

PYZCHIVA Co-pay Terms and Conditions: Limitations apply. Valid only for those with private commercial insurance. Prescription must be for an approved indication. Restrictions, including monthly and/or annual maximums may apply. Patient is responsible for any costs once program limit is reached. Program not valid (i) if prescription for PYZCHIVA is paid, in whole or in part, under Medicare (including Part D, even in the coverage gap), Medicaid, Medigap, TRICARE, VA, DoD, or any other federal or state health care program, (ii) where patient is not using insurance coverage at all, (iii) where the patient's insurance plan reimburses for the entire cost of the drug, or (iv) where product is not covered by patient's insurance. The value of this program is exclusively for the benefit of patients and is intended to be credited towards patient out-of-pocket obligations and maximums, including applicable co-payments, coinsurance, and deductibles. It is a violation of the terms and conditions of this program to use it to enroll patients for the purposes of a copay accumulator or maximizer program. Sandoz reserves the right to take any appropriate action against any person or entity using the program in violation of the terms and conditions. Program is not valid where prohibited by law. Patient may not seek reimbursement for the value received from this program from other parties, including any health insurance program or plan, flexible spending account, or health care savings account. Patient is responsible for complying with any applicable limitations and requirements of their health plan related to the use of the Program. Valid only in the United States and US Territories (Puerto Rico, Guam, Northern Mariana Islands, and Virgin Islands). This Program is not health insurance. Program may not be combined with any third-party rebate, coupon, or offer. Proof of purchase may be required. Co-pay program has no cash value. Additional terms and conditions may apply. Sandoz reserves the right to rescind, revoke, or amend the Program and discontinue support at any time without notice.

Questions?

Call 1-855-SANDOZ-8 (1-855-726-3698) to speak with a Sandoz One Source Case Manager

Case Managers

  • Provide education about PYZCHIVA
  • Help identify opportunities for savings

Injection support

  • Personalized, 1:1 training options available
  • Nurse support to answer questionse

Insurance support

  • Assistance with navigating and understanding your health plan benefits
  • Help with identifying a pharmacy that will arrange shipment of your medication to you

eNurses do not provide medical advice. Please discuss therapy with your healthcare provider.

Patient Authorization Form for PYZCHIVA

If you have not completed the Patient Authorization Form for PYZCHIVA, please fill out the online form. This is required for you to be enrolled in Sandoz One Source and receive support services.

Get your information to go!

Download this helpful brochure to learn more about PYZCHIVA.

Download

Frequently Asked Questions (FAQs)

A biosimilar is a type of biologic medicine. Although they are not exactly the same, you can think of a biosimilar as being like a generic medicine. Like generics, biosimilars can be used in place of a name-brand medicine because they deliver results that are just as safe and effective.

PYZCHIVA is a biosimilar to Stelara® (ustekinumab). There are no differences between PYZCHIVA and Stelara® when it comes to safety, effectiveness, and quality. This means you can expect the same results with PYZCHIVA that you experience with Stelara®.

Yes. PYZCHIVA is an FDA-approved biosimilar, which means it was thoroughly studied before being presented to the FDA. This proved that there are no differences between PYZCHIVA and Stelara® when it comes to safety, effectiveness, and quality.

When it comes to symptom relief, safety, and quality, you can expect the same experience with PYZCHIVA that you’ve had with Stelara®.

PYZCHIVA is a biosimilar to Stelara®. There are no differences between PYZCHIVA and Stelara® when it comes to safety, effectiveness, and quality. This means you can expect the same results with PYZCHIVA that you experience with Stelara®.

However, medicines like PYZCHIVA, are not for everyone; only your doctor can decide if PYZCHIVA is right for you.

PYZCHIVA is a prescription medicine that affects your immune system. It can increase your chance of having serious side effects including serious infections, cancer, serious allergic reactions, lung inflammation, and a rare condition called posterior reversible encephalopathy syndrome.

These are not all the possible side effects of PYZCHIVA. Please read the Important Safety Information located at the bottom of the screen and the Medication Guide for PYZCHIVA to learn more about these and other risks for PYZCHIVA. Discuss any questions you have with your doctor.

In clinical studies, the most common side effects were:

  • nasal congestion, sore throat, and runny nose
  • upper respiratory infections
  • fever
  • headache
  • tiredness
  • itching
  • nausea and vomiting
  • redness at the injection site
  • vaginal yeast infections
  • urinary tract infections
  • sinus infection
  • bronchitis
  • diarrhea
  • stomach pain
  • joint pain

These are not all of the possible side effects of PYZCHIVA. Tell your doctor about any side effect that you experience. Call your doctor for medical advice about side effects.

You should not receive a live vaccine while taking PYZCHIVA. Before receiving PYZCHIVA, tell your doctor if you have recently received or are scheduled to receive an immunization (vaccine). Tell your doctor if anyone in your house needs a vaccine. The viruses used in some types of vaccines can spread to people with a weakened immune system, and can cause serious problems. You should not receive the BCG vaccine during the one year before taking PYZCHIVA or one year after you stop taking PYZCHIVA.

Sandoz One Source is committed to offering support for people who have been prescribed PYZCHIVA. Services such as Case Managers, a Co-Pay Program, and injection support help make the process of starting or switching to PYZCHIVA simple. Learn more about services from Sandoz One Source.

With the PYZCHIVA Co-Pay Program, eligible people with commercial insurance may pay as little as $0 for their treatment. Click below to see the full Terms and Conditions.d

  • If you qualify, you can start using your co-pay card right away
  • Your card doesn’t expire—you’ll be automatically re-enrolled every year

PYZCHIVA Co-pay Terms and Conditions: Limitations apply. Valid only for those with private commercial insurance. Prescription must be for an approved indication. Restrictions, including monthly and/or annual maximums may apply. Patient is responsible for any costs once program limit is reached. Program not valid (i) if prescription for PYZCHIVA is paid, in whole or in part, under Medicare (including Part D, even in the coverage gap), Medicaid, Medigap, TRICARE, VA, DoD, or any other federal or state health care program, (ii) where patient is not using insurance coverage at all, (iii) where the patient's insurance plan reimburses for the entire cost of the drug, or (iv) where product is not covered by patient's insurance. The value of this program is exclusively for the benefit of patients and is intended to be credited towards patient out-of-pocket obligations and maximums, including applicable co-payments, coinsurance, and deductibles. It is a violation of the terms and conditions of this program to use it to enroll patients for the purposes of a copay accumulator or maximizer program. Sandoz reserves the right to take any appropriate action against any person or entity using the program in violation of the terms and conditions. Program is not valid where prohibited by law. Patient may not seek reimbursement for the value received from this program from other parties, including any health insurance program or plan, flexible spending account, or health care savings account. Patient is responsible for complying with any applicable limitations and requirements of their health plan related to the use of the Program. Valid only in the United States and US Territories (Puerto Rico, Guam, Northern Mariana Islands, and Virgin Islands). This Program is not health insurance. Program may not be combined with any third-party rebate, coupon, or offer. Proof of purchase may be required. Co-pay program has no cash value. Additional terms and conditions may apply. Sandoz reserves the right to rescind, revoke, or amend the Program and discontinue support at any time without notice.

If you don’t qualify for the Co-pay Program, Sandoz One Source may be able to connect you to other opportunities for financial support.

PYZCHIVA is brought to you by Sandoz, a company with 25+ years of experience in biosimilars. Sandoz was the first company to have an FDA-approved biosimilar in the US and currently has more than 10 FDA-approved biosimilar medicines.

Important Safety Information and Indications

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What is PYZCHIVA® (ustekinumab-ttwe)?
PYZCHIVA is a prescription medicine used to treat:

  • adults and children 6 years and older with moderate to severe psoriasis who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills)
  • adults and children 6 years and older with active psoriatic arthritis
  • adults 18 years and older with moderately to severely active Crohn’s disease
  • adults 18 years and older with moderately to severely active ulcerative colitis

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about PYZCHIVA?

Do not take PYZCHIVA if you are allergic to ustekinumab or any of the ingredients in PYZCHIVA.

PYZCHIVA is a prescription medicine that affects your immune system. PYZCHIVA can increase your risk of having serious side effects, including:

Serious Infections: PYZCHIVA may lower your ability to fight infections and may increase your risk of infections. Some people have serious infections while taking PYZCHIVA, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses. Some people have to be hospitalized for treatment of their infection.

  • Your doctor should check you for TB before starting PYZCHIVA and watch you closely for signs and symptoms of TB during treatment with PYZCHIVA
  • If your doctor feels that you are at risk for TB, you may be treated for TB before and during treatment with PYZCHIVA

You should not start taking PYZCHIVA if you have any kind of infection unless your doctor says it is okay.

Before starting PYZCHIVA, tell your doctor if you:

  • think you have an infection or have symptoms of an infection such as:

    • fever, sweat, or chills
    • muscle aches
    • cough
    • shortness of breath
    • blood in phlegm
    • weight loss
    • warm, red, or painful skin or sores on your body
    • diarrhea or stomach pain
    • burning when you urinate or urinate more often than normal
    • feel very tired
  • are being treated for an infection or have any open cuts
  • get a lot of infections or have infections that keep coming back
  • have TB or have been in close contact with someone with TB

After starting PYZCHIVA, call your doctor right away if you have any symptoms of an infection (see above). These may be signs of infections such as chest infections, or skin infections or shingles that could have serious complications. PYZCHIVA can make you more likely to get infections or make an infection that you have worse. People who have a genetic problem where the body does not make any of the proteins interleukin 12 (IL-12) and interleukin 23 (IL-23) are at a higher risk for certain serious infections. These infections can spread throughout the body and cause death. People who take PYZCHIVA may also be more likely to get these infections.

Cancers: PYZCHIVA may decrease the activity of your immune system and increase your risk for certain types of cancers. Tell your doctor if you have ever had any type of cancer. Some people who are receiving PYZCHIVA and have risk factors for skin cancer have developed certain types of skin cancers. Tell your doctor if you develop any new skin growths.

Posterior Reversible Encephalopathy Syndrome (PRES): PRES is a rare condition that affects the brain and can cause death. The cause of PRES is not known. If PRES is found early and treated, most people recover. Tell your doctor right away if you have any new or worsening medical problems including headache, seizures, confusion, or vision problems.

Serious Allergic Reactions: Serious allergic reactions can occur. Stop using PYZCHIVA and get medical help right away if you have any symptoms of a serious allergic reaction such as feeling faint, swelling of your face, eyelids, tongue, or throat, chest tightness, or skin rash.

Lung Inflammation: Cases of lung inflammation have happened in some people who receive PYZCHIVA and may be serious. These lung problems may need to be treated in a hospital. Tell your doctor right away if you develop shortness of breath or a cough that doesn’t go away during treatment with PYZCHIVA.

Before you receive PYZCHIVA, tell your doctor about all of your medical conditions, including if you:

  • have any of the conditions or symptoms listed above for serious infections, cancers, or PRES
  • ever had an allergic reaction to PYZCHIVA or any of its ingredients. Ask your doctor if you are not sure
  • have recently received or are scheduled to receive an immunization (vaccine). People who take PYZCHIVA should not receive live vaccines. Tell your doctor if anyone in your house needs a live vaccine. The viruses used in some types of live vaccines can spread to people with a weakened immune system and can cause serious problems. You should not receive the BCG vaccine during the one year before receiving PYZCHIVA or one year after you stop receiving PYZCHIVA
  • have any new or changing lesions within psoriasis areas or on normal skin
  • are receiving or have received allergy shots, especially for serious allergic reactions. Allergy shots may not work as well for you during treatment with PYZCHIVA. PYZCHIVA may also increase your risk of having an allergic reaction to an allergy shot.
  • receive or have received phototherapy for your psoriasis
  • are pregnant or plan to become pregnant. It is not known if PYZCHIVA can harm your unborn baby. You and your doctor should decide if you will receive PYZCHIVA
  • received PYZCHIVA while you were pregnant. It is important that you tell your baby’s healthcare provider before any vaccinations are given to your baby
  • are breastfeeding or plan to breastfeed. PYZCHIVA can pass into your breast milk
  • Talk to your doctor about the best way to feed your baby if you receive PYZCHIVA

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

When prescribed PYZCHIVA:

  • Use PYZCHIVA exactly as your doctor tells you to
  • PYZCHIVA is intended for use under the guidance and supervision of your doctor. In children 6 years and older, it is recommended that PYZCHIVA be administered by a healthcare provider. If your doctor decides that you or a caregiver may give your injections of PYZCHIVA at home, you should receive training on the right way to prepare and inject PYZCHIVA. Your doctor will determine the right dose of PYZCHIVA for you, the amount for each injection, and how often you should receive it. Do not try to inject PYZCHIVA yourself until you or your caregiver have been shown how to inject PYZCHIVA by your doctor or nurse

Keep PYZCHIVA and all medicines out of the reach of children.

Common side effects for PYZCHIVA include nasal congestion, sore throat, and runny nose; upper respiratory infections; fever; headache; tiredness; itching; nausea and vomiting; redness at the injection site; vaginal yeast infections; urinary tract infections; sinus infection; bronchitis; diarrhea; stomach pain; and joint pain. These are not all of the possible side effects with PYZCHIVA. Tell your doctor about any side effect that you experience. Ask your doctor or pharmacist for more information.

Please see your doctor to discuss any questions you may have.

Please see full Prescribing Information, including Medication Guide, for PYZCHIVA.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-8​0​0-FDA-1​0​8​8.

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